The calciferol receptor (VDR) is a protein that is stimulated by vitamin D. It comparison of data room software is involved in maintaining the mineral harmony in the body and leading to growth and hair production. It also interacts with adipose tissue.
VDRs happen to be expressed inside the parathyroid glands, intestines, epithelial cells, and many immune cell types. They are considered to regulate the intestinal consumption of calcium supplements, and to mediate some of the associated with vitamin D on bone routine service. Fortunately they are thought to play an important purpose in metabolic process.
VDR is found in a variety of flesh, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they are really most widely depicted in the kidneys and bone.
The VDR is phosphorylated about serine residues by a lot of protein kinases. These kinases include PKA and PKC. The effect of the kinases in VDR can be ligand based mostly. Specifically, the phosphorylation of Ser51 simply by PKC decreased VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.
Studies have shown that VDRs exist in a subset of glial cells, specifically in oligodendrocytes in white subject. Although VDR immunoreactivity has been detected in a number of glial cell lines, no proof has been offered that the existence of VDR in glia is a cause of increased risk of tumorigenesis.
Additionally , VDR is apparently present in a subset of neurons. In fact , nuclear discoloration has been confirmed in person cortex and glial cell-lines.
A large 220-kDa protein can be found in human key glioblastoma skin cells. In contrast, a tiny recombinant VDR-like protein was produced.